What will happen after you get methotrexate? After you get methotrexate, you may have: mild to moderate cramps or pain in the abdomen ; vaginal bleeding (like a period) Your doctor will likely want you to have a blood test 2 to 3 times a week, for 2 to 3 weeks. This is to tell if the methotrexate worked to stop the pregnancy. methotrexate for ectopic pregnancy – july 2017 page 1 of 2 This information is for patients who have been diagnosed with an ectopic pregnancy and need to have treatment with methotrexate medication. Methotrexate to Treat Ectopic Pregnancy What is ectopic pregnancy? Ectopic [ek-TOP-ik] means “out of place” — and in an ectopic pregnancy, the fertilized egg has implanted outside the uterus (the womb). Most ectopic pregnancies occur in a fallopian [fuh-LOW-pee-uh n] tube, which is why they are sometimes called “tubal pregnancies.” But a fertilized egg can also settle in the abdomen. The management of ectopic pregnancy (EP) by systemic methotrexate administration (MTX) represents an interesting alternative to the conservative laparoscopic treatment. Twenty to forty five percent of ectopic pregnancies can be treated by MTX with the same success rate as conservative laparoscopic treatment. Since the introduction of this method in our department, 25 % of EP have been treated. Bonjour, j'ai pris du méthotrexate pendant 5 ans pour traiter une polyarthrite je suis mieux, mais avec de gros effets secondaires : très grosse fatigue, inflammation de la muqueuse buccale manque, baisse des globules rouges ,baisse des globules blancs et des plaquettes diarrhée; nausées, douleurs abdominales, perte d'appétit, malaise ;et aussi perte de poids…. Treatment of ectopic pregnancy with Methotrexate is not appropriate if you suffer from any of the following conditions: – An ongoing infection – Severe anaemia or shortage of other blood cells – Kidney problems – Liver problems – Active infection – HIV/AIDS – Peptic ulcer or ulcerative colitis.